Involvement of apoptosis and autophagy in reducing mouse hepatoma ML-1 cells growth in inbred BALB/c mice by bacterial fermented soybeans products

dc.contributor 國立臺灣師範大學人類發展與家庭學系 zh_tw
dc.contributor.author Su, C.-L., Chen, F.-N., and Won, S.-J., en_US
dc.date.accessioned 2014-12-02T06:40:02Z
dc.date.available 2014-12-02T06:40:02Z
dc.date.issued 2011-01-01 zh_TW
dc.description.abstract Followed by the results of our previousn vitroeport (Food Chem. Toxicol., 2007), the efficacy of the soybean fermentation products containing live bacteria (SCB) was demonstrated using a syngeneic animal model. Murine HBV-related hepatoma ML-1 cells, derived from inbred animals and tumorigenic in BALB/c mice, were implanted subcutaneously to the flank of BALB/c mice on day 0. Three days after implantation, SCB (1.0 or 1.3l/mouse/day) or vehicle (water) was orally administrated daily until day 60. The results indicate that SCB significantly reduced (P�<�0.05) the volumes and weights of tumors during the experimental periods. Examination using TUNEL staining on section of tumors revealed apoptotic phenomenon of nuclear DNA double-strand breaks in the groups of mice received SCB. Immunohistochemistry further revealed an autophagic LC3-II punctate pattern. Of note, SCB induced autophagy in the absence or presence of apoptosis, whereas, apoptosis was observed only in combination with autophagy.n vitrotudy using autophagy inhibitor indicated that the induction of autophagy promoted apoptosis. These data imply that the suppression in tumor volumes and tumor weights by oral administration of SCB was due to the induction of apoptotic and autophagic cell death, which suggests therapeutic potential of SCB on HBV-related HCC. en_US
dc.description.uri http://www.sciencedirect.com/science/article/pii/S0278691510005272 zh_TW
dc.identifier ntnulib_tp_A0307_01_003 zh_TW
dc.identifier.issn 0278-6915 zh_TW
dc.identifier.uri http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/41467
dc.language en_US zh_TW
dc.publisher Elsevier en_US
dc.relation Food and Chemical Toxicology, 49, 17-24. en_US
dc.relation.uri http://dx.doi.org/10.1016/j.fct.2010.08.017 zh_TW
dc.subject.other Fermented soybeans en_US
dc.subject.other Syngeneic animal model en_US
dc.subject.other Apoptosis en_US
dc.subject.other Autophagy en_US
dc.subject.other Hepatoma cells en_US
dc.subject.other BALB/c mice en_US
dc.title Involvement of apoptosis and autophagy in reducing mouse hepatoma ML-1 cells growth in inbred BALB/c mice by bacterial fermented soybeans products en_US
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