Involvement of apoptosis and autophagy in reducing mouse hepatoma ML-1 cells growth in inbred BALB/c mice by bacterial fermented soybeans products

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dc.contributor國立臺灣師範大學人類發展與家庭學系zh_tw
dc.contributor.authorSu, C.-L., Chen, F.-N., and Won, S.-J.,en_US
dc.date.accessioned2014-12-02T06:40:02Z
dc.date.available2014-12-02T06:40:02Z
dc.date.issued2011-01-01zh_TW
dc.description.abstractFollowed by the results of our previousn vitroeport (Food Chem. Toxicol., 2007), the efficacy of the soybean fermentation products containing live bacteria (SCB) was demonstrated using a syngeneic animal model. Murine HBV-related hepatoma ML-1 cells, derived from inbred animals and tumorigenic in BALB/c mice, were implanted subcutaneously to the flank of BALB/c mice on day 0. Three days after implantation, SCB (1.0 or 1.3l/mouse/day) or vehicle (water) was orally administrated daily until day 60. The results indicate that SCB significantly reduced (P�<�0.05) the volumes and weights of tumors during the experimental periods. Examination using TUNEL staining on section of tumors revealed apoptotic phenomenon of nuclear DNA double-strand breaks in the groups of mice received SCB. Immunohistochemistry further revealed an autophagic LC3-II punctate pattern. Of note, SCB induced autophagy in the absence or presence of apoptosis, whereas, apoptosis was observed only in combination with autophagy.n vitrotudy using autophagy inhibitor indicated that the induction of autophagy promoted apoptosis. These data imply that the suppression in tumor volumes and tumor weights by oral administration of SCB was due to the induction of apoptotic and autophagic cell death, which suggests therapeutic potential of SCB on HBV-related HCC.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/pii/S0278691510005272zh_TW
dc.identifierntnulib_tp_A0307_01_003zh_TW
dc.identifier.issn0278-6915zh_TW
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/41467
dc.languageen_USzh_TW
dc.publisherElsevieren_US
dc.relationFood and Chemical Toxicology, 49, 17-24.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.fct.2010.08.017zh_TW
dc.subject.otherFermented soybeansen_US
dc.subject.otherSyngeneic animal modelen_US
dc.subject.otherApoptosisen_US
dc.subject.otherAutophagyen_US
dc.subject.otherHepatoma cellsen_US
dc.subject.otherBALB/c miceen_US
dc.titleInvolvement of apoptosis and autophagy in reducing mouse hepatoma ML-1 cells growth in inbred BALB/c mice by bacterial fermented soybeans productsen_US

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