變場及低場核磁共振系統於人類肝癌組織檢測應用與特性研究
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2019
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在手術當中的緊急狀況會採用較快速的切片如冷凍切片，此方式需要病理醫師進行判斷，並非容易取得的方式，因此需要一個快速量化的方法。所以本研究使用了變場式核磁共振儀與低場核磁共振系統來進行核磁共振的參數量測，透過變場的量測得到不同頻率下腫瘤組織與正常組織的R1，並且建立了R1與頻率之間的關係，也驗證各個頻率下使用R1來進行腫瘤分辨的可行性。接著使用實驗室的低場核磁共振系統進行了30組樣品的量測，從結果得到腫瘤組織與正常組織在R1上有顯著的分辨，顯示了低場在腫瘤組織臨床應用有可行性，未來有機會提供量化的腫瘤檢測。
Emergency situations during surgery use faster sections such as cryosections, which requires a pathologist to make judgments that are not readily available, and therefore require a rapid quantification method. So, this study use Fast-Field Cycling Nuclear Magnetic Resonance (FFC-NMR) and Low-Field Nuclear Magnetic Resonance (LF-NMR) to measure the NMR parameters. Through the measurement of the variable field, the R1 of tumor tissue and normal tissue at different frequencies were obtained, and established the relationship of R1 and frequency. The relationship between the two also verifies the feasibility of using R1 for tumor discrimination at each frequency. Then, using low-field NMR system of our laboratory, 30 sets of samples were measured. From the results, the tumor tissue and normal tissue were significantly distinguished on R1, indicating that the low-field NMR system is feasible in clinical application of tumor tissue. It is possible to provide quantitative tumor detection in the future.
Emergency situations during surgery use faster sections such as cryosections, which requires a pathologist to make judgments that are not readily available, and therefore require a rapid quantification method. So, this study use Fast-Field Cycling Nuclear Magnetic Resonance (FFC-NMR) and Low-Field Nuclear Magnetic Resonance (LF-NMR) to measure the NMR parameters. Through the measurement of the variable field, the R1 of tumor tissue and normal tissue at different frequencies were obtained, and established the relationship of R1 and frequency. The relationship between the two also verifies the feasibility of using R1 for tumor discrimination at each frequency. Then, using low-field NMR system of our laboratory, 30 sets of samples were measured. From the results, the tumor tissue and normal tissue were significantly distinguished on R1, indicating that the low-field NMR system is feasible in clinical application of tumor tissue. It is possible to provide quantitative tumor detection in the future.
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變場式核磁共振儀, 低場核磁共振系統, R1弛緩速率, 腫瘤檢測, Fast-field-Cycling NMR, Low-field NMR, Relaxation rate (R1), Tumor detection