變溫磁粒子頻譜儀於磁流體之諧波及溫度特性之應用與研究
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2021
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磁性奈米粒子在物理及生醫方面都有重要的研究應用，利用磁性奈米粒子在高頻強交流磁場下的產熱特性，可被應用於腫瘤熱治療，當腫瘤細胞被加熱超過43 ℃即可造成腫瘤細胞凋亡，然而，生物體內的溫度檢測是目前所遇到的問題之一。為了解決這個問題，本研究開發了可溫控微型磁流體頻譜儀，用來檢測磁粒子諧波與溫度的關係，該裝置由一個激發線圈和一對方向相反的梯度接收線圈組成，以消除背景磁場並提高檢測系統的訊雜比，由於樣品和檢測線圈之間的距離較短，因此可以實現高檢測靈敏度和低樣品的消耗。為了使實驗的溫度控制更穩定，所以本微型磁流體頻譜儀整合了一組溫度控制系統，使實際溫度與目標溫度的差異保持在± 0.1~0.2 ℃之間，實現了溫度穩定控制的目標，磁粒子頻譜儀系統量測之交流磁化訊號經過傅立葉轉換後，可得到磁性奈米粒子於外加交流場下的諧波特性，其諧波訊號強度會隨著溫度增加而減少，利用頻譜之三倍頻及五倍頻的強度比值( I5th/3rd )，來比較不同濃度的磁性樣品在不同磁場下的諧波與溫度特性，再透過多項式得到諧波強度與溫度的特性曲線，發現在不同磁場或濃度下，所得到的I5th/3rd經過歸一化後，隨著溫度下降的趨勢線會接近重合，可以從本實驗結果來驗證諧波訊號應用於溫度檢測之可能性，未來可以用於腫瘤熱治療法之體外溫度監控等生醫應用上。
Magnetic nanoparticles have important research applications in physics and biomedicine. Using the heat-generating properties of magnetic nanoparticles under a high-frequency and strong AC magnetic field, they can be used in tumor thermal therapy, when the tumor cells are heated to over 43℃. Causes tumor cell apoptosis. However, temperature detection in the organism is one of the problems encountered at present. To solve this problem, this research has developed a temperature-controllable miniature magnetic fluid spectrometer to detect the relationship between magnetic particle harmonics and temperature. The device consists of an excitation coil and a pair of gradient receiving coils in opposite directions to eliminate background The magnetic field also improves the signal-to-noise ratio of the detection system. Due to the short distance between the sample and the detection coil, high detection sensitivity and low sample consumption can be achieved.To make the temperature control of the experiment more stable, this miniature magnetic fluid spectrometer integrates a set of temperature control systems to keep the difference between the actual temperature and the target temperature within ± 0.1 ~ 0.2 ℃, achieving the goal of stable temperature control. After Fourier transformation of the AC magnetization signal measured by the magnetic particle spectrometer system, the harmonic characteristics of the magnetic nanoparticle under an external AC field can be obtained. The intensity of the harmonic signal will decrease with the increase of temperature, using three times the frequency spectrum. To compare the harmonic and temperature characteristics of magnetic samples with different concentrations under different magnetic fields, the intensity ratio between the frequency and the five-fold frequency (I5th/3rd) is used to obtain the characteristic curve of the harmonic intensity and temperature through a polynomial. At the concentration, the obtained I5th/3rd will be normalized, and the trend line will be close to coinciding as the temperature drops. The results of this experiment can be used to verify the possibility of harmonic signals for temperature detection, which can be used for tumor fever in the future. Biomedical applications such as external temperature monitoring in the treatment method.
Magnetic nanoparticles have important research applications in physics and biomedicine. Using the heat-generating properties of magnetic nanoparticles under a high-frequency and strong AC magnetic field, they can be used in tumor thermal therapy, when the tumor cells are heated to over 43℃. Causes tumor cell apoptosis. However, temperature detection in the organism is one of the problems encountered at present. To solve this problem, this research has developed a temperature-controllable miniature magnetic fluid spectrometer to detect the relationship between magnetic particle harmonics and temperature. The device consists of an excitation coil and a pair of gradient receiving coils in opposite directions to eliminate background The magnetic field also improves the signal-to-noise ratio of the detection system. Due to the short distance between the sample and the detection coil, high detection sensitivity and low sample consumption can be achieved.To make the temperature control of the experiment more stable, this miniature magnetic fluid spectrometer integrates a set of temperature control systems to keep the difference between the actual temperature and the target temperature within ± 0.1 ~ 0.2 ℃, achieving the goal of stable temperature control. After Fourier transformation of the AC magnetization signal measured by the magnetic particle spectrometer system, the harmonic characteristics of the magnetic nanoparticle under an external AC field can be obtained. The intensity of the harmonic signal will decrease with the increase of temperature, using three times the frequency spectrum. To compare the harmonic and temperature characteristics of magnetic samples with different concentrations under different magnetic fields, the intensity ratio between the frequency and the five-fold frequency (I5th/3rd) is used to obtain the characteristic curve of the harmonic intensity and temperature through a polynomial. At the concentration, the obtained I5th/3rd will be normalized, and the trend line will be close to coinciding as the temperature drops. The results of this experiment can be used to verify the possibility of harmonic signals for temperature detection, which can be used for tumor fever in the future. Biomedical applications such as external temperature monitoring in the treatment method.
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Keywords
腫瘤熱治療, 磁性奈米粒子, 交流磁化率, tumor hyperthermia, magnetic nanoparticles, alternating magnetic susceptibility