Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells is partly through inhibition of Aurora-A

Simple item page
dc.contributor國立臺灣師範大學人類發展與家庭學系zh_tw
dc.contributor.authorLiu, H.-S., Ke, C.-S., Cheng, H.-C., Huang, C.-Y. F., and Su, C.-L.,en_US
dc.date.accessioned2014-12-02T06:40:02Z
dc.date.available2014-12-02T06:40:02Z
dc.date.issued2011-10-01zh_TW
dc.description.abstractCurcumin, an active compound in turmeric and curry, has been proven to induce tumor apoptosis and inhibit tumor proliferation, invasion, angiogenesis, and metastasis via modulating numerous targets in various types of cancer cells. Aurora A is a mitosis-related serine-threonine kinase and plays important roles in diverse human cancers. However, the effect of curcumin on Aurora A has not been reported. In this study, Aurora A promoter activity and mRNA expression were inhibited in curcumin-treated human bladder cancer T24 cells, suggesting that Aurora A is regulated at the transcription level. We also found that curcumin preferentially inhibited the growth of T24 cells, which show a higher proliferation rate, invasion activity,and expression level of Aurora A compared with that of human immortalized uroepithelial E7cells. Furthermore, inhibition of phosphorylation of Aurora A and its downstream target histone H3 accompanied by the formation of monopolar spindle, induction of G2 /M phase arrest, and reduction in cell division in response to curcumin were detected in T24 cells. These curcumin-induced phenomena were similar to those using Aurora A small interfering RNA and were attenuated by ectopic expression of Aurora A. Therefore, the antitumor mechanism of curcumin is Aurora A-related, which further supports the application of curcumin in treatments of human cancers.en_US
dc.description.urihttp://molpharm.aspetjournals.org/content/80/4/638.full.pdfzh_TW
dc.identifierntnulib_tp_A0307_01_001zh_TW
dc.identifier.issn1521-0111zh_TW
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/41465
dc.languageen_USzh_TW
dc.publisherThe American Society for Pharmacology and Experimental Therapeuticsen_US
dc.relationMolecular Pharmacology, 80(4), 638-646.en_US
dc.relation.urihttp://dx.doi.org/10.1124/mol.111.072512zh_TW
dc.titleCurcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells is partly through inhibition of Aurora-Aen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ntnulib_tp_A0307_01_001.pdf
Size:
2.22 MB
Format:
Adobe Portable Document Format
Download

Collections

教師著作