多通道陣列式磁粒子造影系統開發與特性 研究應用於生物影像

Abstract

在本研究中，架設多通道陣列式磁粒子造影系統 (MagneticParticleImaging,MPI)，透過使用梯度線圈作為擷取線 圈，能夠快速動態成像，具有極低之系統背景值，在交流磁 場下，量測磁性奈米粒子之訊號，應用最小範數估計演算法 及非負線性最小平方演算法重建影像分佈。系統所量測最 小樣品含鐵量為 0.691675 mg，系統最大可量測區域為直徑 15 cm，建立移動樣品方法，架設自動控制移動平台，使本 系統有最佳影像解析度為 10 mm，開發局限座標法，進行 影像分析，使影像更加貼近於實際樣品，實現磁粒子造影的 功能性影像與磁振造影的結構性影像之整合的醫學影像。

In this work we propose a magnetic particle imaging (MPI) by using an array of gradient pick-up coils for fast dynamic imaging and sensitive quantifying magnetic nano-particles (MNPs). We detect the magnetic signal from MNPs under an ac exciting field and apply the minimum-norm estimation to reconstruct MNPs' distribution. A detection sensitivity of 0.691675mg Fe content is achieved and a fast dynamic imaging with the imaging area of 15 × 15 cm2 is demonstrated. We combine the image of MPI with the image of MRI to locate the exact position of subjects and the distribution of MNPs. The proposed array MPI shows high detection sensitivity and fast dynamic imaging, and is promise in biomedical applications.