High prevalence of hyperuricemia in elderly Taiwanese

dc.contributor 國立臺灣師範大學人類發展與家庭學系 zh_tw
dc.contributor.author Lee MS, Lin SC, Chang HY, Lyu LC, Tsai KS, Pan WH en_US
dc.date.accessioned 2014-12-02T06:39:42Z
dc.date.available 2014-12-02T06:39:42Z
dc.date.issued 2005-06-01 zh_TW
dc.description.abstract Serum urate status, the prevalence of hyperuricemia and their relationship to the metabolic syndrome in elderly Taiwanese were described using data from the Elderly Nutrition and Health Survey in Taiwan (1999-2000), in which a stratified multi-stage clustered sampling scheme was applied. Complete data from biochemical assays and anthropometric measures for 1225 males and 1167 females were included in the analysis. The mean urate level and 95% confidence interval was 411 (398, 424) microM for males and 357 (347, 367) microM for females. Males had significantly higher serum urate levels than females across all age groups (P<0.05). No significant difference in mean serum urate was found among the four age groups of males. On the other hand, females of 75-79 years had significantly higher serum urate levels (376 microM) than that of the 65-69 and>or=80 age groups. The overall prevalence of hyperuricemia (>or=416.7 microM (7.0 mg/dL) in the elderly was 36% (46% for males and 26% for females). Among the participants, 4.2% of males and 1.1% of females were taking medication to lower uric acid. The elderly (males 455 microM; females 416 microM) of the Mountain areas, mainly indigenes, had the highest mean serum urate overall, however, the highest prevalence of hyperuricemia in males was found in the PengHu islands (62%) and that for females in the Mountain areas (51%). The odds ratio (OR) for hyperuricemia was 2.84 for males in the PengHu islands and 4.33 for females in Mountain areas, compared with their counterparts in the third stratum in the northern areas. Adjusting for obesity, alcohol and other related covariates did not alter the relative rank of the ORs in the various strata. Elderly males (22%) had a significantly lower rate of metabolic syndrome (MS) than females (39%) (P<0.05). For both genders, those with MS had a significantly higher mean serum urate (males 436 microM vs. 405 microM; females 389 microM vs. 338 microM) and prevalence of hyperuricemia (males 56% vs. 43%; females 38% vs.19%) (P<0.05). The population attributable risk for MS from hyperuricemia was 18.8% in men and 15.5% in women. In conclusion, the mean serum urate and prevalence of hyperuricemia in the elderly in Taiwan were higher than those found in other populations and was significantly associated with MS. Gene-environmental interaction may play a key role since great geographical variation exists within various Han Chinese groups in Taiwan and between Han Chinese and Taiwanese indigenes. en_US
dc.description.uri http://apjcn.nhri.org.tw/server/apjcn/Volume14/vol14.3/fullArticles/Lee.pdf zh_TW
dc.identifier ntnulib_tp_A0304_01_013 zh_TW
dc.identifier.issn 1440-6047 zh_TW
dc.identifier.uri http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/41228
dc.language en_US zh_TW
dc.publisher Asia Pacific Health and Nutrition Centre zh_tw
dc.relation Asia Pac J Clin Nutr, 14(3), 285-292. en_US
dc.subject.other serum urate en_US
dc.subject.other hyperuricemia en_US
dc.subject.other metabolic syndrome (MS) en_US
dc.subject.other elderly en_US
dc.subject.other indigenous en_US
dc.subject.other mountainous en_US
dc.subject.other Taiwan en_US
dc.subject.other Elderly Nutrition and Health Survey in Taiwan (1999-2000) en_US
dc.title High prevalence of hyperuricemia in elderly Taiwanese en_US
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
389.76 KB
Adobe Portable Document Format