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Design a series gating and non-gating respiration control auxiliary system for external beam radiation therapy system
其自製的模擬系統由兩個線性驅動器和一個可移動平台組成，最大移動範圍為12.5 cm x 6.5cm x 5 cm，可以精確模擬8位患者的呼吸模式，誤差小於6.3％，最大運動差為1.16 mm，晶片的傳輸信號以波形的方式顯示。經由八位志願者的測試，該晶片可以檢測深度到達3mm的深呼吸運動。晶片對6 MV光子的400 MU和10 MV光子的200 MU的輻射劑量的影響結果顯示穿透率分別達98.8% 及98.6%，其對光束衰減的影響小，數值小於1.4％。
Stereotactic ablative radiotherapy (SABR) aims to deliver high doses of radiation to kill cancer cells and shrink tumors in less or equals to 6 fractions. However, organ motion during treatment is a challenging issue for this kind of technique. We try to develop a control system via Bluetooth technology to simulate and correct the body motion during SABR. A homemade chip to monitor position and surface movement was made and a simulation system was assembled by 3D printing technique. Radiation doses were analysis and the capability of radiation damage protection was checked by EBT3 films irradiated by a linear accelerator. Wireless signal test was also done. Validation was done by 8 previous treated patients respiratory pattern records and 8 healthy volunteers. The home-made simulation system was consisted of 2 linear actuators and one movable stage with maximal moving distance 12.5 cm x 6.5cm x 5 cm could simulate the 8 patients’ respiratory pattern precisely with less than 6.3% error and maximal difference of motion was 1.16 mm, and chipset transited signals to displays them as a waveform. From 8 volunteers test, the chip could detect the deep respiratory movement up to 3 cm. The effect of the chip on the radiation dose 400 MU by 6 MV photon and 200 MU by 10 MV photon were all showed high penetration rate 98.8% and 98.6%, respectively. In the other word ,the least influence on the beam attenuation, less than 1.4%. We invented a tubeless and wireless respiratory gating detection chip. It has minimal interference to the treatment angles, good noise immunity and easily penetrate variety of materials capability. The simulation system consisted by linear actuators also simulates the real patients’ respiratory pattern successfully. We also developing similar system for the treatment system cooperate with MR environment. It will be done the whole things with about one year.
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