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科技與工程學院
光電工程研究所
學位論文
學位論文
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http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/73896
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search.filters.author.周彥廷
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search.filters.subject.gradiometer
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search.filters.subject.longitudinal relaxation time
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search.filters.subject.low field NMR
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search.filters.subject.SQUID
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Author: search.filters.author.周彥廷
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低磁場核磁共振梯度接收線圈應用於肝腫瘤組織檢驗
(
2014
)
周彥廷
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本研究中,我們整合結合超導量子干涉元件(superconducting quantum interference device, SQUID)和預極化技術,提高低磁場核磁共振系統的量測訊雜比,並將此系統應用於肝腫瘤檢測。為了解決在非磁屏蔽環境下,測量磁場隨環境磁場漂移,而導致磁共振頻率飄移的問題,我們使用磁通閘監控環境磁場之變化,作為磁共振訊號頻率修正之參考,成功增加了訊號頻譜之訊雜比。然在量測微量樣品時,為了降低環境雜訊並避免冷卻預極化線圈的循環水的訊號被量測到。我們採用了梯度接收線圈的設計,成功消除了循環水的訊號。在1.5 高斯的主磁場、930高斯的預極化磁場之條件下,進行了微量(0.5 ~ 0.1 g)之老鼠腫瘤與正常肝組織之縱向鬆弛時間(T1)之量測,與0.5 g 老鼠肝臟腫瘤與正常組織之混合樣品之鬆弛時間檢測。驗證本研究之低場磁共振系統具臨床應用的潛力。
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