吳學亮Wu, Hsyueh-Liang簡嘉宏Jian, Jia-Hong2020-10-192025-01-052020-10-192020http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G080442009S%22.&%22.id.&http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/111191本論文利用銠金屬催化試劑針對去氫丙胺酸107、113或β取代硝基烯酸酯128進行一系列不對稱加成反應，可以得到具有高產率與良好鏡像超越值之加成產物。並且透過同位素實驗以及DFT理論計算推測其催化反應路徑中的配基效應、質子化步驟和立體效應。此方法能夠有效合成出掌性α-或β2-胺基酸及其衍生物。A highly enantioselective rhodium-catalyzed conjugate addition reactions of dehydroalanines 107, 113 and β-nitroacrylates 128 with a variety of aryl boronic acids is described, providing an access to both chiral α- and β2-amino acid derivatives in good yields and enantioselectivities. Mechanistic studies which include deuterium labelling experiments and DFT calculations supported the ligand-assisted, protonation step and the stereochemical effect of mechanism. Thses method were applied for the synthesis of α-and β2-amino acid derivatives.銠金屬催化試劑胺基酸加成反應rhodium-catalyzedamino acidconjugate addition