王忠茂呂威良2019-09-04不公開2019-09-042009http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN0696420571%22.&%22.id.&http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100727摘要 氟化奎林酮化合物（fluoroquinolone，簡稱FLQ）是敏光性物質，若在含氧環境中照光，會進行脫氟反應，而產生出HF2-。UV-Vis吸收光譜與螢光放射光譜分析也獲得同樣結論，僅在有機相與水相中分解時所得產物不盡相同。 藉由N-acetyl-3,7-dihydroxy-phenoxazine（簡稱amplex red）與發光胺(3-aminophthalhydrazide，簡稱luminol)的化學發光與電致發化學發光光反應，我們證實FLQ化合物在有氧環境中照光，會產生高反應性含氧化合物。我們繼而探討所生成的高氧化性含氧化合物對二溴丙酸、溴丙醇及溴酚的分解反應，發現FLQ化合物具有分解含溴有機物的應用潛力。此外，有們也發現：激發態的FLQ化合物可與過氧化氫反應，導致其螢光強度會隨過氧化氫濃度增加而增高，可藉以對過氧化氫進行定量分析。Abstract Fluoroquinolone compounds (FLQ) are potential photosensitizers. As subjected to UV irradiation, they can undergo photodecomposition, and thereby, release carbene and HF2-. UV-Visible absorption and fluorescence emission spectroscopicanalyses evidenced this potential and, in addition, showed that although the photodecomposition products in organic solvents were different from in aqueous systems, oxygen could accelerate the decomposition rate. The released carbene could further trigger the formation of reactive oxygen species such as OH. and O2-. in aqueous solutions if oxygen was in the presence. By using N-acetyl-3,7-dihydroxy-phenoxazine (denoted amplex red) and 3-aminophthalhydrazide (luminol) as probes, we confirmed the formation of OH. and O2-. radicals, and thereby, used it to photodegrade brominated organic compounds, such as 2,3-dibromopropionic acid. Besides, most FLQ showed potential to react with H2O2 as they were brought into the excited state. Because of this, FLQ turned out to be an effective probe for the analysis of H2O2.氟化奎林酮