許春峰陳朝棟洪志明王澄霞2014-10-272014-10-271984-06-??http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/17540滅殺除癌（Methotrexate, MTX）是一種於癌症化學療法中被廣泛使用的藥物。2.4一二氨基－6－取代嘧啶哌嗪（6）可作為合成MTX的起始反應物。本研究分別從嘧啶衍生物（Pyrimidine derivatives）及派嗪 衍生物（Pyrazine derivatives）合成化合物（6）。Methotrexate (MTX) is an important anticancer drug widely used in cancer chemotherapy. 2,4-Diamino-6-substitued pteridine (6) is the intermediate for MTX. In this research the intermediate (6) was synthesized from a pyrimidine deri-vative and also from a pyrazire derivative.一二氨基合成嘧啶哌嗪