王鶴森Ho-Seng Wang陳厚諭Hou-Yu Chen2019-09-052009-8-232019-09-052008http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN0694300387%22.&%22.id.&http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/105656摘要 目的：探討咖啡因增補對不同體能水準者於離心運動後所引起的延遲性肌肉酸痛 (delayed onset muscle soreness, DOMS) 之生理及生化反應的影響。方法：依最大耗氧量分成10名高體能組 (HF；VO2max＝54.5 ± 3.75 毫升/公斤/分) 及10名低體能組 (LF；VO2max＝44.7 ± 3.06 毫升/公斤/分)之大學男生，先於跑步機上以70%VO2max的強度進行一次30分鐘的下坡跑 (–15% 斜度) 誘發股四頭肌產生DOMS，所有受試者於誘發DOMS後依雙盲設計及組內平衡次序法於第一天及第二天分別增補咖啡因或安慰劑膠囊10 mg ･ kg–1，並在增補前、後測量最大自主等長肌力、酸痛指數、肌酸激酶、乳酸脫氫酶及組織胺。實驗所得資料採混合設計二因子變異數分析進行統計處理。結果：在增補因子方面，HF組與LF組在增補咖啡因後所提升的最大自主等長肌力百分比 (HF：7.0 ± 9.9 %, LF：5.1 ± 10.8 %)，皆顯著高於增補安慰劑 (HF：-0.1 ± 4.7 %, LF：0.4 ±5.2 %; p＜.05)；咖啡因增補後降低的酸痛指數百分比 (HF：-18.2 ± 22.2 %, LF：-11.9 ± 11.3 %)，亦顯著低於增補安慰劑 (HF：7.2 ± 18.5 %, LF：1.7 ± 11.5 %; p＜.05)；兩組在肌酸激酶、乳酸脫氫酶及組織胺於增補咖啡因或安慰劑後改變之活性值，皆未達到顯著差異。結論：1.誘發 DOMS後增補10 mg ･ kg–1之咖啡因能顯著降低運動中肌肉酸痛及顯著提升最大自主等長肌力，此種效果不會因為體能水準不同而改變。2.咖啡因的增補雖能顯著降低肌肉酸痛之不適感，但並非因為降低了發炎與損傷的程度。 關鍵詞：咖啡因、延遲性肌肉酸痛、體能水準Abstract Purpose: The purpose of this study was to examine the effects of caffeine ingestion on delayed onset muscle soreness (DOMS) in men of different fitness levels. Methods: Ten high fitness level (HF; VO2max＝54.5 ± 3.75 ml/kg/min) and ten low fitness level (LF; VO2max＝44.7 ± 3.06 ml/kg/min) college males performed a 30 minutes downhill running (-15% ) to elicit DOMS. All subjects ingested caffeine 24 or 48 hors after exercise induced DOMS under double-blind controlled. We measured maximal voluntary isometric contractions (MVIC), perceived muscle soreness scale, creatine kinase (CK), lactate dehydrogenase (LDH) and histamine activity one hour before and after caffeine ingestion. Data were analyzed by a mixed design two-way ANOVA. Results: After caffeine ingestion, HF and LF of participants were significantly increased in MVIC force % (HF：7.0 ± 9.9 %, LF：5.1 ± 10.8 %) than placebo ingestion (HF：-0.1 ± 4.7 %, LF：0.4 ±5.2 %; p＜.05), in addition, the muscle soreness scale % (HF：-18.2 ± 22.2 %, LF：-11.9 ± 11.3 %) was significantly reduced than placebo ingestion (HF：7.2 ± 18.5 %, LF：1.7 ± 11.5 %; p＜.05). However, there was no significant difference between two fitness levels in CK, LDH and histamine activity. Conclusions: 10 mg ･ kg-1 body weight dose of caffeine could increase the MVIC and reduce pain after exercise induced DOMS, and these effects independent of fitness level. Key words: caffeine, DOMS, fitness level咖啡因延遲性肌肉酸痛體能水準caffeineDOMSfitness level