姜宏哲王佩蓮2014-10-272014-10-271981-06-??http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/17704The synthetic methods of 2'-deoxy-5-fluorouridine (an antitumor drug) reported in-literature were extensively reviewed and discussed.The most economical synthetic route is the method modifide by Brown(5) 2', 3', 5'-Tri-O-acetyluridine was allowed to react with acetic acid containing fluorine. The reaction mixture was treated with ammonia in methyl alcohol to give 5-fluououridine. which was then deoxygenated to give the 2'-deoxy-5-fluorouridinein the overall yield 71%.合成法抗腫瘤藥物