林文偉wen-wei, Lin陳錡翰chi-han, Chen2019-09-04不公開2019-09-042014http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN060042053S%22.&%22.id.&http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100365a,b-不飽和-1,3-雙酮和亞烷基丙二腈為起始物透過奎寧進行連續性的二次 Michael 加成反應，得到具有兩個立體中心的多取代環己酮衍生物，產率為 59-94%、單一非鏡像異構物和高達 92% 的鏡像超越值。organocatalytic asymmetric double Michael addition reaction of a,b-unsaturated-1,3-diketones to 2-alkylidene malononitriles 80 has been investigated with quinine as the catalyst to afford a range of multi-substituted cyclohexanones bearing two sterecenters in good results (58-94% yield, >99:1 de, and up to 92% ee).連續性反應環己酮鏡像選擇性Domino reactionCyclohexanoneEnantioselectivity