劉宏文Liu, Hung-Wen余姵璇Yu, Pei-Hsuan2023-12-082028-08-122023-12-082023https://etds.lib.ntnu.edu.tw/thesis/detail/aa82aea0739530fdf6803eecd9dd8c0d/http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/121472背景：運動訓練藉由能量赤字與抑制食慾，以作為有效管理體重的策略。近期研究顯示女性有氧運動抑制食慾的效果在月經黃體中期減弱。然而尚無研究針對月經週期的不同階段，進行阻力運動對食慾的影響。目的：本研究探討單次阻力運動，在月經週期的不同階段對於食慾、食物偏好與實際能量攝取之影響。方法： 11 名經期規律的健康女性 (年齡22.6 ± 1.3歲)，依平衡次序法執行四次試驗：濾泡早期運動 (Exercise Follicular phase, EF)；黃體中期運動 (Exercise Luteal phase, EL)；濾泡早期休息 (Control Follicular phase, CF)；黃體中期休息 (Control Luteal phase, CL)。阻力運動以70% 1 RM強度，執行三組七下，動作依序為：槓鈴深蹲、槓鈴臥推與六角槓硬舉。並於空腹、介入前、後立即、後30分鐘、後60分鐘與後90分鐘等六時間點測量受試者之主觀食慾、食物偏好、乳酸、雌二醇、黃體素、皮質醇，隨後午餐提供自由進食 (ad libitum)，以及記錄三日飲食以評估實際能量攝取。使用里茲食物偏好問卷評估運動後30分鐘與午餐進食前後之食物偏好。所得數據將以混合線性模型 (linear-mixed model) 進行分析。結果：乳酸於介入後立即與介入後30分鐘，運動試驗顯著高於休息試驗 (p< 0.05)，且 EF於介入後立即顯著高於 EL (p = 0.019)。雌二醇之時間點變化量，EL 顯著高於 CL (p = 0.004)。黃體素之時間點變化量於介入後立即，EL 顯著高於 CL 與 EF (p < 0.05)；於介入後30分鐘與介入後90分鐘，EL 顯著高於 EF (p < 0.05)。整體主觀食慾感受於介入後立即與介入後30分鐘，EF 顯著低於 CF (p < 0.05)，且 EL 於介入後立即也有低於 CF 的趨勢。里茲食物偏好與午餐後自由進食在各介入間沒有顯著差異 (p > 0.05)。實際能量攝取，CL 顯著高於 CF 與 EL (p < 0.05)。結論：經期規律的健康女性於濾泡早期與黃體中期進行阻力運動都會產生較高的乳酸濃度，並造成抑制主觀食慾的效果。於黃體中期進行阻力運動後，觀察到所產生乳酸濃度比濾泡早期低，推測與雌性激素降低糖解代謝有關。在實際能量攝取上，女性於黃體中期進行阻力運動有更大的進食量抑制效果。Introduction: Exercise training-induced appetite suppression and energy expenditure can aid in weight management. Recent studies have indicated that intense aerobic exercise-induced appetite suppression is blunted in the luteal phase compared to the follicular phase. However, the effects of resistance exercise on appetite regulation in women remains largely unclear. Purpose: This study aimed to investigate the effects of menstrual cycle (early-follicular phase and mid-luteal phase) on appetite, food preference and energy intake in response to resistance exercise in healthy young women. Methods: Eleven healthy young women (aged: 22.6 ± 1.3) completed four counter-balanced trials: exercise during the follicular phase (EF), exercise during the luteal phase (EL), control during the follicular phase (CF), and control during the luteal phase (CL). Participants performed resistance exercises in the following order: squat, bench press, deadlift. Each exercise consisted of 3 sets with 7 repetitions, using a load of 70% 1RM. Subjective appetite perceptions, food preference, lactate, estradiol, progesterone, and cortisol were measured pre-exercise, and at 0-, 30-, 60-, 90-minute intervals post-exercise. Energy intake was recorded on the day before the experiment, the day of the experiment, and the day after the experiment. Results: Lactate levels in the exercise trials were significantly higher than in the control trials immediately and 30 minutes post-exercise (p< 0.05), with lactate levels in the EF being significantly higher than those in the EL immediately post-exercise (p = 0.019). The change in estradiol levels was significantly higher in the EL than in the CL (p = 0.004). Additionally, the change in progesterone levels was significantly higher in the EL than in the CL and EF immediately post-exercise (p < 0.05), and this difference persisted at the 30-minute and 90-minute post-exercise (p < 0.05). Subjective appetite perceptions in the EF was significantly lower than that in the CF immediately and 30 minutes post-exercise (p< 0.05), while the EL exhibited a tendency to be lower than the CL. However, no significant differences were found in food preference and ad libitum among the four trial conditions. Energy intake in the CL was significantly higher than that in the CF and EL (p < 0.05). Conclusion: In healthy women with regular menstruation, resistance exercise-induced hyperlactatemia suppresses subjective appetite during both the early follicular phase and mid-luteal phase. It was observed that resistance exercise-induced hyperlactatemia was lower in the mid-luteal phase, which could be related to the reduction of glycolysis by estrogen. Furthermore, healthy women performing resistance exercise during the mid-luteal phase had a greater inhibition of food intake compared to the early follicular phase.無氧運動穩態系統享樂系統濾泡期黃體期雌二醇乳酸anaerobic exercisehomeostatic systemhedonic systemfollicular phaseluteal phaseestradiollactateetd