林文偉Lin, Wen-wei王瑩錚Wang, Ying-Zheng2019-09-04不公開2019-09-042017http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060442102S%22.&%22.id.&http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100165第一章、利用新穎的四組成有機鏻鹽高效的合成雙雜環化合物 利用高效的方式生成四組成有機鏻鹽進行分子內 Wittig 反應合成雙雜環化合物，過程無使用金屬試劑，條件溫和，反應中間物穩定易操作，是為傳統偶合反應的替代方案。 第二章、利用聚苯乙烯負載有機磷試劑進行可回收再生之Wittig反應以合成雙雜環化合物 透過固相載體進行反應以簡化純化的步驟及減少試劑的浪費，進而達到環保效益的概念。Chapter I: Efficient synthesis of bis-heteroarenes using of novel four-components of organic phosphonium salts An efficient synthetic strategy for bis-heteroarenes has been developed under metal-free conditions. The isolable phosphonium salts obtained via a novel four-component reaction could undergo further acylation and Wittig reaction to produce the bis-heteroarenes. This synthetic strategy can provide an efficient alternative method to the traditional metal-mediated cross-coupling strategies. Chapter II: Using of polystyrene-bonded organophosphorus reagent for reproducible regeneration of the Wittig reaction to synthesize bis-heteroarenes A organophosphorus reagent bonded solid supports was used for intramolecular wittig reactions to generate indole-benzofuran cross-coupling type product. This strategy has simplified purification steps, reduce the waste of reagents, phosphine oxide, and achieve the concept of environmental benefits.威悌反應有機鏻鹽雙雜環Wittig reactionPhosphonium SaltsBis-heteroarenes