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First, we have developed a novel technique by using functionalized magnetic nanoparticles to recognize the specific biomarker of human heart disease under MALDI-MASS spectrometer. The technique provided a rapid, sensitive and highly specific detection platform for the bio-marker assay. The techniques also allowed us to detect several disease markers spontaneously within one hour. In comparison to current known detective techniques, our new method was relatively cheaper and much easier to be operated in daily clinical operation. Secondly, fluorescent silica nanotubes have been successfully synthesized and applied for the studies of their activity inside living cells. The specific DNA inside the hollow silica nanotubes was able to enter the cells with the access of the nanotubes and then the gene expression of the cells was observed. This work was, for the first time, to apply silica nanotubes for the gene delivery. Third, we have successfully synthesized semiconductor quantum dots encapsulated inside dentric polymers. The new functionalized quantum dots were highly water-soluble and bio-comparable. The materials were suitable for developing new bio-labeling applications. Finally, a series of carbohydrate encapsulated gold nanoparticles were prepared. For the first time, we have found that the new functionalized gold nanoparticles can generate strong multi-valence binding to their targeting protein.
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