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|Abstract:||The synthetic methods of 2'-deoxy-5-fluorouridine (an antitumor drug) reported in-literature were extensively reviewed and discussed.The most economical synthetic route is the method modifide by Brown(5) 2', 3', 5'-Tri-O-acetyluridine was allowed to react with acetic acid containing fluorine. The reaction mixture was treated with ammonia in methyl alcohol to give 5-fluououridine. which was then deoxygenated to give the 2'-deoxy-5-fluorouridinein the overall yield 71%.|
|Appears in Collections:||師大學報|
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