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Title: 2'-去氧-5-氟脲核苷(抗腫瘤藥物)之合成法研討
Authors: 姜宏哲
Issue Date: Jun-1981
Publisher: 國立臺灣師範大學研究發展處
Office of Research and Development
Abstract: The synthetic methods of 2'-deoxy-5-fluorouridine (an antitumor drug) reported in-literature were extensively reviewed and discussed.The most economical synthetic route is the method modifide by Brown(5) 2', 3', 5'-Tri-O-acetyluridine was allowed to react with acetic acid containing fluorine. The reaction mixture was treated with ammonia in methyl alcohol to give 5-fluououridine. which was then deoxygenated to give the 2'-deoxy-5-fluorouridinein the overall yield 71%.
Other Identifiers: D2E609D5-F4B8-2C25-A6FD-8C00269ACEA8
Appears in Collections:師大學報

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