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Title: Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones
Authors: 國立臺灣師範大學人類發展與家庭學系
Jou HJ, Wu SC, Chang FW, Ling PY, Chu KS, Wu WH*
Issue Date: 1-Jul-2008
Publisher: Elsevier
Abstract: Objective:To evaluate the effect of soy isoflavones on menopausal symptoms in women who do and who do not produce equol, a daidzein metabolite. Method:A randomized, double-blind, placebo-controlled clinical trial was conducted over 6 months with 96 healthy menopausal women. After taking take 135 mg of isoflavones daily for 1 week, the women in the study group were assigned to the equol-producing (EP) or the non-EP group according to the presence or absence of equol in their urine. Menopausal symptoms were evaluated using a modified Kupperman Index. Result:Compared with the placebo group, the scores for hot flashes and excessive sweating were significantly reduced after 3 months, and the scores for weakness, palpitations, limb paresthesia, and total symptoms after 6 months, in the EP group only. Conclusions:Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.
ISSN: 0020-7292
Other Identifiers: ntnulib_tp_A0305_01_005
Appears in Collections:教師著作

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